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P R Flatt Selected Research

(pGlu-Gln)-CCK-8

8/2013Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes.
7/2013Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed mice.
6/2013Beneficial effects of (pGlu-Gln)-CCK-8 on energy intake and metabolism in high fat fed mice are associated with alterations of hypothalamic gene expression.
6/2013Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice.
10/2012Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes.

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P R Flatt Research Topics

Disease

34Type 2 Diabetes Mellitus (MODY)
03/2024 - 06/2000
34Body Weight (Weight, Body)
01/2023 - 09/2000
34Insulin Resistance
01/2020 - 12/2002
30Obesity
04/2024 - 02/2003
7Glucose Intolerance
01/2015 - 09/2000
3Necrosis
05/2006 - 04/2002
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
09/2015 - 02/2000
2Hyperphagia (Overeating)
02/2011 - 04/2008
2Diabetes Mellitus
12/2002 - 01/2001
1Inflammation (Inflammations)
12/2019
1Neurodegenerative Diseases (Neurodegenerative Disease)
12/2019
1Cognitive Dysfunction
04/2015
1Morbid Obesity
05/2013
1Hyperinsulinism (Hyperinsulinemia)
11/2008
1Metabolic Syndrome (Dysmetabolic Syndrome X)
05/2006
1Vascular Diseases (Vascular Disease)
05/2006
1Insulinoma
12/2002
1Hyperglycemia
01/2001

Drug/Important Bio-Agent (IBA)

37Glucose (Dextrose)FDA LinkGeneric
01/2023 - 09/2000
32Insulin (Novolin)FDA Link
12/2019 - 02/2000
17Peptides (Polypeptides)IBA
03/2024 - 01/2001
14Glucagon-Like Peptide 1 (GLP 1)IBA
12/2019 - 12/2003
12Hormones (Hormone)IBA
03/2024 - 12/2003
12gastric inhibitory polypeptide receptorIBA
02/2015 - 07/2007
10Pro(3)- glucose-dependent insulinotropic polypeptideIBA
02/2015 - 02/2003
10Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA
02/2015 - 07/2007
7IncretinsIBA
01/2019 - 02/2003
5Glucagon (Glukagon)FDA Link
10/2016 - 01/2001
5Triglycerides (Triacylglycerol)IBA
04/2015 - 09/2009
5(pGlu-Gln)-CCK-8IBA
08/2013 - 10/2012
5glycated insulinIBA
02/2006 - 09/2000
3Exenatide (Byetta)FDA Link
12/2019 - 08/2010
3LipidsIBA
09/2015 - 07/2007
3Insulin SecretagoguesIBA
01/2015 - 01/2001
3monomethoxypolyethylene glycol (MPEG)IBA
08/2013 - 11/2008
3Cholecystokinin (Pancreozymin)IBA
08/2013 - 10/2012
3Hypoglycemic Agents (Hypoglycemics)IBA
09/2002 - 01/2001
2Sitagliptin Phosphate (Januvia)FDA Link
04/2024 - 04/2015
2xenin 25 (xenin)IBA
01/2020 - 06/2015
2Blood Glucose (Blood Sugar)IBA
01/2016 - 06/2013
2LiraglutideFDA Link
05/2013 - 10/2010
2EnzymesIBA
06/2009 - 12/2003
2Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
05/2005 - 12/2003
2exendin (9-39)IBA
05/2005 - 02/2003
12- (4- acetoxyphenyl)- 2- chloro- N- methylethylamineIBA
04/2024
1MicroRNAs (MicroRNA)IBA
03/2024
1GastrinsIBA
12/2019
1Neuroprotective AgentsIBA
12/2019
1Glucagon-Like Peptide-1 Receptor AgonistsIBA
12/2019
1apelin-13 peptideIBA
01/2018
1Sodium-Glucose Transporter 2 InhibitorsIBA
01/2016
1biphalinIBA
01/2016
1OxyntomodulinIBA
09/2015
1CholesterolIBA
04/2015
1C-PeptideIBA
10/2014
1Cholecystokinin Receptors (Cholecystokinin Receptor)IBA
08/2013
1Glucagon Receptors (Glucagon Receptor)IBA
06/2013
1Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA
06/2013
1MelanocortinsIBA
06/2013
1Dietary Fats (Dietary Fat)IBA
10/2010
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
12/2009
1Mifepristone (RU 486)FDA Link
12/2009
1Streptozocin (Streptozotocin)FDA Link
04/2008
1GhrelinIBA
05/2007
1Peptide Hormones (Polypeptide Hormones)IBA
05/2007
1Sucrose (Saccharose)IBA
03/2007
1CarbohydratesIBA
03/2007
1fenugreek seed mealIBA
03/2007
1SolutionsIBA
11/2006
1gastric inhibitory polypeptide (3-42)IBA
10/2006
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
06/2006
1HomocysteineIBA
05/2006
1Sorbitol (Yal)FDA Link
09/2005
1Glucagon-Like Peptide-1 ReceptorIBA
05/2005
1Metformin (Glucophage)FDA LinkGeneric
05/2005
1N-pyroglutamyl- glucagon-like peptide-1 (7-36)amideIBA
03/2004
1SecretagoguesIBA
09/2003
1Nateglinide (Starlix)FDA LinkGeneric
09/2003
1Proteins (Proteins, Gene)FDA Link
12/2002
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
12/2002
1Cytotoxins (Cytolysins)IBA
12/2002
1Acridine OrangeIBA
12/2002
1Interleukin-1beta (Interleukin 1 beta)IBA
04/2002
1Interferon-gamma (Interferon, gamma)IBA
04/2002
1CytokinesIBA
04/2002
1Adenosine Triphosphate (ATP)IBA
04/2002
1glucagon-like peptide 1 (7-37)IBA
01/2001
1Succinic Acid (Succinate)IBA
01/2001
1EstersIBA
01/2001
1Complement System Proteins (Complement)IBA
02/2000
1Culture MediaIBA
02/2000
1Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
02/2000
1Alanine (L-Alanine)FDA Link
02/2000
1Bovine Serum AlbuminIBA
02/2000
1AntibodiesIBA
02/2000
1AutoantibodiesIBA
02/2000

Therapy/Procedure

8Therapeutics
01/2018 - 01/2001
3Injections
10/2016 - 10/2012
2Drug Therapy (Chemotherapy)
12/2019 - 09/2005
1Intraperitoneal Injections
09/2000